Science and Research News

All the very latest OCD science and research news. These reports are provided for your information and resource purposes only, but should not be taken that OCD-UK endorse the research findings or information within these pages.

 

Scientists Probe Meditation Secrets

Scientists are beginning to uncover evidence that meditation has a tangible effect on the brain.

Sceptics argue that it is not a practical way to try to deal with the stresses of modern life. But the long years when adherents were unable to point to hard science to support their belief in the technique may finally be coming to an end.

When Carol Cattley's husband died it triggered a relapse of the depression which had not plagued her since she was a teenager. "I instantly felt as if I wanted to die," she said. "I couldn't think of what else to do."

Carol sought medical help and managed to control her depression with a combination of medication and a psychological treatment called Cognitive Behavioural Therapy (CBT).

However, she believes that a new, increasingly popular course called Mindfulness Based Cognitive Therapy (MBCT) - which primarily consists of meditation - brought about her full recovery. It is currently available in every county across the UK, and can be prescribed on the NHS.

One of the pioneers of MBCT is Professor Mark Williams, from the Department of Psychiatry at the University of Oxford. He helps to lead group courses which take place over a period of eight weeks. He describes the approach as 80% meditation, 20% cognitive therapy.

New perspective

He said: "It teaches a way of looking at problems, observing them clearly but not necessarily trying to fix them or solve them. It suggests to people that they begin to see all their thoughts as just thoughts, whether they are positive, negative or neutral."

MBCT is recommended for people who are not currently depressed, but who have had three or more bouts of depression in their lives. Trials suggest that the course reduces the likelihood of another attack of depression by over 50%. Professor Williams believes that more research is still needed. He said: "It is becoming enormously popular quite quickly and in many ways we now need to collect the evidence to check that it really is being effective."

However, in the meantime, meditation is being taken seriously as a means of tackling difficult and very modern challenges. Scientists are beginning to investigate how else meditation could be used, particularly for those at risk of suicide and people struggling with the effects of substance abuse.

What is meditation?

Meditation is difficult to define because it has so many different forms. Broadly, it can be described as a mental practice in which you focus your attention on a particular subject or object. It has historically been associated with religion, but it can also be secular, and exactly what you focus your attention on is largely a matter of personal choice. It may be a mantra (repeated word or phrase), breathing patterns, or simply an awareness of being alive.

Some of the more common forms of meditative practices include Buddhist Meditation, Mindfulness Meditation, Transcendental Meditation, and Zen Meditation.

The claims made for meditation range from increasing immunity, improving asthma and increasing fertility through to reducing the effects of aging.

Limited research

Research into the health claims made for meditation has limitations and few conclusions can be reached, partly because meditation is rarely isolated - it is often practiced alongside other lifestyle changes such as diet, or exercise, or as part of group therapy.

So should we dismiss it as quackery? Studies from the field of neuroscience suggest not. It is a new area of research, but indications are intriguing and suggest that meditation may have a measurable impact on the brain.

In Boston, Massachusetts, Dr Sara Lazar has used a technique called MRI scanning to analyse the brains of people who have been meditating for several years. She compared the brains of these experienced practitioners with people who had never meditated and found that there were differences in the thickness of certain areas of the brain's cortex, including areas involved in the processing of emotion. She is continuing research, but she believes that meditation had caused the brain to change physical shape.

Buddhist monks

In Madison, Wisconsin, Dr Richard Davidson has been carrying out studies on Buddhist monks for several years. His personal belief is that "by meditating, you can become happier, you can concentrate more effectively and you can change your brain in ways that support that."

In one study he observed the brains of a group of office workers before and after they undertook a course of meditation combined with stress reduction techniques. At the end of the course the participants' brains seemed to have altered in the way they functioned. They showed greater activity in the left-hand side - a characteristic which Davidson has previously linked to happiness and enthusiasm.

This idea that meditation could improve the wellbeing of everyone, even those not struggling with mental illness, is something that is exciting researchers. Professor Williams believes it has huge potential. "It involves dealing with expectations, with constantly judging ourselves - feeling we're not good enough," he said.

"And, that is something which is so widespread in our communities.

"All of these things are just thoughts. And, they will come up in meditation and learning to recognize what they are as thoughts, and let them go, can be enormously empowering for anybody."

There is, of course, a distinct possibility that this research will come to nothing and that interest in meditation will turn out to be a passing fad, but for now this ancient discipline is being taken seriously by scientists as a tool with potential to make each one of us happier and more content.

 

Brain pattern associated with genetic risk of OCD

Cambridge researchers have discovered that individuals with obsessive compulsive disorder (OCD) and their close family members have distinctive patterns in their brain structure. This is the first time that scientists have associated an anatomical trait with familial risk for the disorder.

These new findings, reported today in the journal Brain, could help predict whether individuals are at risk of developing OCD and lead to more accurate diagnosis of the disorder.

Obsessive compulsive disorder is a prevalent illness that affects 2–3 % of the population. OCD patients suffer from obsessions (unwanted, recurrent thoughts, concerns with themes of contamination and ‘germs’, the need to check household items in case of fire or burglary, the symmetrical order of objects or fears of harming oneself or others) as well as compulsions (repetitive behaviours related to the obsessions such as washing and carrying out household safety checks). These symptoms can consume the patient’s life, causing severe distress, alienation and anxiety.

OCD is known to run in families. However, the complex set of genes underlying this heritability and exactly how genes contribute to the illness are unknown. Such genes may pose a risk for OCD by influencing brain structure (e.g. the amount and location of grey matter in the brain) which in turn may impact upon an individual’s ability to perform mental tasks.

In order to explore this idea, the researchers used cognitive and brain measures to determine whether there are biological markers of genetic risk for developing OCD. Using magnetic resonance imaging (MRI), the Cambridge researchers captured pictures of OCD patients’ brains, as well as those of healthy close relatives (a sibling, parent or child) and a group of unrelated healthy people.

Participants also completed a computerised test that involved pressing a left or right button as quickly as possible when arrows appeared. When a beep noise sounded, volunteers had to attempt to stop their responses. This task objectively measured the ability to stop repetitive behaviours.

Both OCD patients and their close relatives fared worse on the computer task than the control group. This was associated with decreases of grey matter in brain regions important in suppressing responses and habits.

Lara Menzies, in the Brain Mapping Unit at the University of Cambridge, explains, “Impaired brain function in the areas of the brain associated with stopping motor responses may contribute to the compulsive and repetitive behaviours that are characteristic of OCD. These brain changes appear to run in families and may represent a genetic risk factor for developing the condition. The current diagnosis of OCD available to psychiatrists is subjective and therefore knowledge of the underlying causes may lead to better diagnosis and ultimately improved clinical treatments.

“However, we have a long way to go to identify the genes contributing to the distinctive brain structure found in OCD patients and their relatives. We also need to identify other contributing factors for OCD, to understand why close relatives that share similar brain structures don’t always develop the disorder.”

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