Clomipramine

(Brand Name: Anafranil)

Clomipramine was first discovered in 1964 by the Swiss drug manufacturer Ciba-Geigyr and was the first drug that was investigated for and found to be effective in the treatment of OCD. The effectiveness of clomipramine in the treatment of OCD is far greater than that of other Tricyclic antidepressants (TCAs) and is the only non SSRI that the NICE guidelines recommend outside of SSRI medications.

Key Facts:
  • Clomipramine can cause withdrawal symptoms so don’t stop taking it without talking to your doctor

Medication Information

Skeletal formula of clomipramine

Skeletal formula of Clomipramine

The following information is a guide only, a doctor may want to try dosages outside these recommended guides.

When: Usually at bedtime.

Child dose: Not recommended.

Adult dose: The initial dose for adults is 25mg daily, as a single dose,  however, it may be started at a lower dose and increased gradually over 2 weeks to 100–150 mg and up to a maximum of 250 mg per day.

Older people: The initial dose for older adults is 10mg daily, as a single dose,  however, it may be started at a lower dose and gradually increased gradually over 2 weeks to 100–150 mg and up to a maximum of 250 mg per day.

Half-Life: 19-37 hours.

The NICE guidelines, published in November 2005, reported that Clomipramine should be considered in the treatment of adults with OCD or BDD after an adequate trial of at least one SSRI has been ineffective or poorly tolerated, or if the patient prefers Clomipramine or has had success in using the medication before.

 

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