Paroxetine

(Brand Name: Paxil, Seroxat)

Marketing of Paroxetine began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Subsequent generic formulations have been available since 2003 when the patent expired.  Paroxetine is available on prescription in either tablet or liquid drop form which you take with water.

  • It usually takes 4 to 6 weeks for Paroxetine to work
  • NHS Choices report that Paroxetine can affect an unborn baby, so it is important to tell your doctor straight away if you’re trying to get pregnant or become pregnant while taking it
  • Take Paroxetine once a day. You can take it with or without food
  • If you have epilepsy – Paroxetine can increase your seizures so tell your doctor
  • If you have an eye problem called glaucoma tell your doctor because Paroxetine can increase eye pressure
  • If you have diabetes, Paroxetine can make it more difficult to keep your blood sugar stable. Monitor your blood sugar more often for the first few weeks of taking and consult your doctor
  • In the United States, the FDA require all antidepressants including Paroxetine to carry a warning  that antidepressants may increase the risk of suicide in people younger than 25

Medication Information

Skeletal formula of Paroxetine.

Skeletal formula of Paroxetine.

The following information is a guide only, a doctor may want to try dosages outside these recommended guides.

Form: Tablets come in different strengths ranging from 10mg to 30mg. With Paroxetine in liquid form, 10ml is the equivalent to a 20mg tablet.

When: Take Paroxetine once a day, in the morning. It’s best to take it with food so it doesn’t upset your tummy.

Child dose: Not recommended for children.

Adult dose: The initial dose for adults is 20mg daily increased in gradual steps of 10 mg to 40 mg daily. Although there is no evidence of greater efficacy at higher doses it can be taken to a  maximum dose of 60 mg per day.

Older people: The initial dose for older people is 20mg daily increased in gradual steps of 10 mg to 40 mg daily.

Half-Life: 21 hours. If you occasionally forget to take a dose, because of the long half-life don’t worry and if you remember before you go to bed, take it straight away. Carry on as usual the next day. If you only remember during the night, or the next day, leave out the missed dose and carry on as usual the next day.

Drug interactions: Don’t take St John’s wort, the herbal remedy, while you are taking Sertraline as this will increase your risk of side effects.

Pregnancy and Breast Feeding: Paroxetine is generally not recommended in pregnancy or while breastfeeding. A doctor will want to prescribe this medication only when the benefits of you taking the medicine outweigh the risks. Paroxetine and similar antidepressants have been linked with a small risk of problems for the unborn baby when taken in early or late pregnancy and Paroxetine is thought to pass into breast milk and has been linked with side effects, including withdrawal symptoms, in breastfed babies.

 

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